DIO1 / TXDI1

deiodinase, iodothyronine, type I

DIO1 / TXDI1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.

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Proteins (3)

Type

Recombinant (3)

Target

DIO1 / TXDI1 (3)

Publications

No (3)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Species

Human (2)

Rat (1)

Source

E. coli (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human DIO1 / TXDI1 Protein (Recombinant GST, N-terminus) (aa35-125) - LS-G58335

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DIO1 / TXDI1 Protein (Recombinant GST) (Full Length) - LS-G28205

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

33.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Rat DIO1 / TXDI1 Protein (Recombinant His, N-Terminal) (Thr31-Phe257) - LS-G133067

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

27kDa

Price:

10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,841

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