DIAPH1

diaphanous-related formin 1

Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

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Proteins (9)

Type

Over-Expression Lysate (5)

Recombinant (4)

Target

DIAPH1 (9)

Publications

No (9)

Tag

GST, N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (7)

Species

Human (7)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

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DIAPH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116100

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.2 kDa

Price:

100 µg/$710

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DIAPH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120118

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

140.1 kDa

Price:

100 µg/$710

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Human DIAPH1 Protein (Recombinant GST, N-terminus) (aa921-1024) - LS-G58333

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DIAPH1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67755

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.2 kDa

Price:

20 µg/$1,107

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Human DIAPH1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67756

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

140.1 kDa

Price:

20 µg/$1,107

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Human DIAPH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80651

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

140.1 kDa

Price:

20 µg/$215

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Human DIAPH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80652

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.2 kDa

Price:

20 µg/$215

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Human DIAPH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80653

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.2 kDa

Price:

20 µg/$215

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Human DIAPH1 Protein (Recombinant His-GST) (aa389-583) - LS-G15987

Source:

E. coli

Tag:

His-GST

Molecular Weight:

54.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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