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DIABLO / SMAC

diablo, IAP-binding mitochondrial protein

Second mitochondria-derived activator of caspase (SMAC) has been implicated in the activation of apoptosis in response to cell stress. SMAC promotes CASP9 activation by binding to IAPs and removing their inhibitory activity. The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/caspase-9 pathway. Smac is an antagonist of the X-linked inhibitor of apoptosis (XIAP) - the most potent caspase inhibitor of all known inhibitor of apoptosis-family members. Smac promotes apoptosis by eliminating the inhibitory effect of inhibitor-of-apoptosis (IAPs) through physical interactions.

Gene Name:	diablo, IAP-binding mitochondrial protein
Family/Subfamily:	Apoptosis , Not assigned-Apoptosis
Synonyms:	DIABLO, DFNA64, DIABLO-S, Diablo homolog, mitochondrial, SMAC3, Mitochondrial Smac protein, SMAC
Target Sequences:	NM_019887 NP_063940.1 Q9NR28

Publications (4)

Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Zhang WH, Wang X, Narayanan M, Zhang Y, Huo C, Reed JC, Friedlander RM. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:16012-7. (ICC, WB; Mouse) [PubMed:14663141] [PMC:PMC307684]

Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors. Liu JC, Deng T, Lehal RS, Kim J, Zacksenhaus E. Cancer research. 2007 67:8671-81. [PubMed:17875707]

Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease. Wang X, Zhu S, Pei Z, Drozda M, Stavrovskaya IG, Del Signore SJ, Cormier K, Shimony EM, Wang H, Ferrante RJ, Kristal BS, Friedlander RM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:9473-85. [PubMed:18799679] [PMC:PMC2632939]

The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity. Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J, Zhou S, Wang H, Zhao R, Yano H, Kim JE, Li W, Kristal BS, Ferrante RJ, Friedlander RM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:14496-507. [PubMed:21994366] [PMC:PMC3213696]

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