DHX8 is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants.
|Gene Name:||DEAH (Asp-Glu-Ala-His) box polypeptide 8|
|Synonyms:||DHX8, DEAD/H BOX 8, DEAH-box protein 8, RNA helicase HRH1, DDX8, DEAH box protein 8, PRP22, PRPF22|
|Target Sequences:||NM_004941 NP_004932.1 Q14562|
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