DHX36

DEAH (Asp-Glu-Ala-His) box polypeptide 36

Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

DHX36 (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

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293T Cells (1)

HEK 293 Cells (2)

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DHX36 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110920

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

114.6 kDa

Price:

100 µg/$710

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Human DHX36 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68531

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

114.6 kDa

Price:

20 µg/$1,107

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Human DHX36 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82401

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

114.6 kDa

Price:

20 µg/$215

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