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DHRS2 / HEP27

dehydrogenase/reductase (SDR family) member 2

Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

Gene Name:	dehydrogenase/reductase (SDR family) member 2
Synonyms:	DHRS2, Dicarbonyl reductase HEP27, HEP27, Protein D, SDR25C1
Target Sequences:	NM_005794 NP_005785.1 Q13268

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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