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DHPS
deoxyhypusine synthase
The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. The DHPS gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.
| Gene Name: | deoxyhypusine synthase |
| Synonyms: | DHPS, Deoxyhypusine synthase, DS, DHS, MIG13, Migration-inducing gene 13 |
| Target Sequences: | NM_001930 NP_001921.1 P49366 |
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