DHCR7

7-dehydrocholesterol reductase

DHCR7 is an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

DHCR7 (6)

Publications

No (6)

Tag

GST (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human DHCR7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80452

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

20 µg/$150

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Human DHCR7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80450

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

20 µg/$150

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Human DHCR7 Protein (Recombinant GST) (Full Length) - LS-G28198

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.9 kDa

Price:

10 µg/$479; 25 µg/$670

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DHCR7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128689

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

100 µg/$494

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Human DHCR7 Protein (Recombinant) (Cys61-Leu153) - LS-G132715

Source:

E. coli

Tag:

None

Price:

10 µg/$288; 50 µg/$487; 200 µg/$972; 100 µg/$780; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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DHCR7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118629

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

100 µg/$494

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