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DGAT1

diacylglycerol O-acyltransferase 1

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

Gene Name: diacylglycerol O-acyltransferase 1
Synonyms: DGAT1, ACAT-related gene product 1, ACAT related gene product 1, ARGP1, ARAT, DGAT, Diglyceride acyltransferase, AGRP1
Target Sequences: NM_012079 NP_036211.2 O75907

Publications (3)

1
High fatty acid availability after exercise alters the regulation of muscle lipid metabolism. Newsom SA, Schenk S, Li M, Everett AC, Horowitz JF. Metabolism: clinical and experimental. 2011 60:852-9. [PubMed:20870251] [PMC:PMC3011035]
2
High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins. Li M, Paran C, Wolins NE, Horowitz JF. American journal of physiology. Endocrinology and metabolism. 2011 300:E699-707. [PubMed:21285405] [PMC:PMC3074947]
3
DGAT1 mutation is linked to a congenital diarrheal disorder. Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. The Journal of clinical investigation. 2012 122:4680-4. (WB; Mouse) [PubMed:23114594] [PMC:PMC3533555]

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ELISA Kits (5)
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DGAT1 (5)
Human (2)
Mouse (2)
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96-Well Strip Plate (5)
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Plasma (4)
Serum (4)
Tissue Homogenates (5)
DGAT1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
DGAT1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
18.75 - 1200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DGAT1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
18.75 - 1200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DGAT1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$893
DGAT1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).