DFFB

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (1, 2, 5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

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Proteins (3)

Type

Recombinant (3)

Target

DFFB (3)

Publications

No (3)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Species

Human (3)

Source

E. coli (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human DFFB Protein (Recombinant GST, N-terminus) (aa229-338) - LS-G58327

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DFFB Protein (Recombinant His-T7) (aa87-323) - LS-G13287

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.9 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human DFFB Protein (Recombinant GST) (Full Length) - LS-G28193

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.5 kDa

Price:

2 µg/$439

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