DFFB

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (1, 2, 5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

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Products

ELISA Kits (8)

Type

Custom (2)

Sandwich (6)

Target

DFFB (8)

Reactivity

Human (2)

Mouse (1)

Rat (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

96-Well Strip Plate (8)

Publications

No (8)

Sample Type

Cell Supernatant (4)

Plasma (6)

Serum (6)

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Rat DFFB (Sandwich ELISA) ELISA Kit - LS-F15823

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse DFFB (Sandwich ELISA) ELISA Kit - LS-F15826

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Bovine DFFB (Custom ELISA) ELISA Kit - LS-F15824

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human DFFB (Custom ELISA) ELISA Kit - LS-F15825

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Monkey DFFB (Sandwich ELISA) ELISA Kit - LS-F74978

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$669

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Human DFFB (Sandwich ELISA) ELISA Kit - LS-F74653

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$598

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Porcine DFFB (Sandwich ELISA) ELISA Kit - LS-F75054

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$669

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Rabbit DFFB (Sandwich ELISA) ELISA Kit - LS-F75086

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$669

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