DFFB

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (1, 2, 5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

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Products

Antibodies (51)

Type

Primary (51)

Target

DFFB (51)

Reactivity

Human (47)

Mouse (21)

Rat (6)

Gibbon (3)

Application

IHC (12)

IHC-P (4)

WB (50)

Flo (8)

ELISA (12)

ICC (3)

IF (4)

Peptide-ELISA (2)

Host

rabbit (48)

mouse (3)

Product Group

IHCPlus (2)

Isotype

IgG (28)

IgG1 (2)

Clonality

monoclonal mc (3)

polyclonal pc (48)

Clone

36A349 (1)

Format

APC (1)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (6)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (4)

Unconjugated (24)

Epitope

C-Terminus (8)

aa87-323 (8)

aa1-30 (7)

aa205-222 (3)

N-Terminus (1)

aa289-338 (1)

Publications

No (51)

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IHC-plus™ DFFB Antibody LS-B559

(4.0) Rating

Antibody:

DFFB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ DFFB Antibody LS-B7893

(4.0) Rating

Antibody:

DFFB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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DFFB Antibody LS-C783101

Antibody:

DFFB Mouse anti-Mouse Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

25 µg/$288; 100 µg/$414

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DFFB Antibody LS-C282

Antibody:

DFFB Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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DFFB Antibody LS-C283

Antibody:

DFFB Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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DFFB Antibody LS-C318

Antibody:

DFFB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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DFFB Antibody (aa1-30) LS-C167374

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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DFFB Antibody (aa1-30) LS-C320816

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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DFFB Antibody (aa1-30, Biotin) LS-C234539

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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DFFB Antibody (aa1-30, FITC) LS-C234538

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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DFFB Antibody (aa1-30, Azide-free, HRP) LS-C249822

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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DFFB Antibody (aa1-30, PE) LS-C234544

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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DFFB Antibody (aa1-30, APC) LS-C234537

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• PE
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • PE
  • APC

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DFFB Antibody LS-C319

Antibody:

DFFB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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DFFB Antibody (aa205-222) LS-C83372

Antibody:

DFFB Rabbit anti-Mouse Polyclonal (aa205-222) Antibody

Reactivity:

Mouse

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$522

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DFFB Antibody LS-C778385

Antibody:

DFFB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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DFFB Antibody (aa205-222) LS-C42801

Antibody:

DFFB Rabbit anti-Mouse Polyclonal (aa205-222) Antibody

Reactivity:

Mouse

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$518

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DFFB Antibody LS-C803615

Antibody:

DFFB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DFFB Antibody (aa289-338) LS-C199781

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa289-338) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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DFFB Antibody LS-C64703

Antibody:

DFFB Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$786

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DFFB Antibody (aa205-222, clone 36A349) LS-C534

Antibody:

DFFB Mouse anti-Human Monoclonal (aa205-222) (36A349 ) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

0.1 mg/$386

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DFFB Antibody LS-C311090

Antibody:

DFFB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

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DFFB Antibody (C-Terminus) LS-C111359

Antibody:

DFFB Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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DFFB Antibody (aa87-323) LS-C293225

Antibody:

DFFB Rabbit anti-Human Polyclonal (aa87-323) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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DFFB Antibody (C-Terminus) LS-C345337

Antibody:

DFFB Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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