DFFA / ICAD / DFF45

DNA fragmentation factor, 45kDa, alpha polypeptide

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45 kD DNA fragmentation factor (DFF45) was identified recently that was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD. DFF45/ICAD have short forms that were termed DFF35 and ICADs, respectively. Upon cleavage of DFF45/ICAD, the caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of DFF45/ICAD, which causes DFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death.

☰ Filters

Products

Proteins (15)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (11)

Target

DFFA / ICAD / DFF45 (15)

Publications

No (15)

Tag

6His, N-terminus (3)

8His, N-terminus (1)

GST (1)

GST, N-terminus (2)

His (1)

His, N-Terminal (2)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (13)

Mouse (1)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (5)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

Select

Mouse DFFA / ICAD / DFF45 Protein (Recombinant His-T7) (aa19-262) - LS-G26103

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.7 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65429

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

20 µg/$1,107

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant 6His, N-terminus) (Met1-Thr331) - LS-G39613

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.7kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant GST, N-terminus) (aa1-331) - LS-G56216

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant GST, N-terminus) (aa231-331) - LS-G58325

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant His, N-Terminal) (Glu2-Thr331) - LS-G96797

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

40 kDa

Price:

10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant His, N-Terminal) (Glu2-Thr331) - LS-G96798

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

40 kDa (large copurified proteins (~100, 250 kDa) due to potential protein interaction)

Price:

10 µg/$289; 200 µg/$646; 50 µg/$360

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant His-T7) (aa51-305) - LS-G16141

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.1 kDa

Price:

50 µg/$447; 10 µg/$282; 200 µg/$892; 100 µg/$715; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

Select

Human DFFA / ICAD / DFF45 Protein (Over-Expression Lysate 8His, N-terminus) (Glu2-Thr331) - LS-G26700

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

37.9 kDa

Price:

100 µg/$298

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant GST) (Full Length) - LS-G28191

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.9 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human DFFA / ICAD / DFF45 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Glu2-Thr331) - LS-G26842

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

37.9 kDa

Price:

200 µl/$283

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant 6His, N-terminus) (Met1-Thr331) - LS-G139071

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.7 kDa

Price:

10 µg/$368; 50 µg/$479

Select

Human DFFA / ICAD / DFF45 Protein (Recombinant His) - LS-G595

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Select

Human DFFA / ICAD / DFF45 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75541

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

20 µg/$150

Select

DFFA / ICAD / DFF45 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116666

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

100 µg/$494

Viewing 1-15 of 15 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.