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Dermatopontin / DPT

dermatopontin

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.

Gene Name:	dermatopontin
Synonyms:	DPT, Dermatopontin, TRAMP
Target Sequences:	NM_001937 NP_001928.2 Q07507

Publications (1)

An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin. Ashley C Kramer, Yuliana Astuti, Alexis Elfstrum, Michael J Lehrke, Jakub Tolar, Bruce R Blazar, Amanda L Blake, Mandy E Taisto, Justin W Furcich, Erin E Nolan, Wilaiwan W Durose, Beau R Webber, Athena Geisness, David K Wood, Troy C Lund. Blood Advances. 2021 Sep;5:3609-3622. [Full Text Article] [PubMed:34448828] [PMC:PMC8945574]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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