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Derlin-3 / DERL3

derlin 3

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.

Gene Name:	derlin 3
Synonyms:	DERL3, C22orf14, Der1-like protein 3, Derlin 3, Derlin-3, DERtrin-3, IZP6, LLN2, DER3, DERtrin 3
Target Sequences:	Q96Q80 Q96Q80

Publications (1)

Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart. Belmont PJ, Chen WJ, San Pedro MN, Thuerauf DJ, Gellings Lowe N, Gude N, Hilton B, Wolkowicz R, Sussman MA, Glembotski CC. Circulation research. 2010 106:307-16. (WB; Rat) [PubMed:19940266] [PMC:PMC3330119] Related Antibodies: LS-C80661.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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