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DERL2 / Derlin-2

derlin 2

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.

Gene Name: derlin 2
Synonyms: DERL2, Carcinoma related, CGI-101, DER2, Derlin 2, Derlin-2, F-LANa, F-LAN-1, FLANa, Der1-like protein 2, DERtrin-2
Target Sequences: NM_016041 NP_057125.2 Q9GZP9

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Products
Antibodies (25)
Primary (25)
DERL2 / Derlin-2 (25)
Human (18)
Mouse (15)
Rat (4)
Bat (3)
Bovine (3)
Chicken (3)
Chimpanzee (3)
Gibbon (3)
Guinea pig (3)
Monkey (3)
Orangutan (3)
Rabbit (3)
IHC (4)
IHC-P (3)
WB (24)
Flo (1)
ELISA (15)
ICC (1)
IF (2)
Peptide-ELISA (1)
rabbit (25)
Product Group
IHCPlus (1)
IgG (15)
polyclonal pc (25)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (12)
aa191-218 (7)
aa191-219 (7)
C-Terminus (5)
N-Terminus (1)
No (25)
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
200 µl/$468
DERL2 / Derlin-2 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DERL2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (aa191-218) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
DERL2 / Derlin-2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DERL2 / Derlin-2 Antibody - Immunochemical staining of human DERL2 in human lymph node with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P
Unconjugated
100 µl/$412
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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DERL2 / Derlin-2 Rabbit anti-Mouse Polyclonal (aa191-219) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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DERL2 / Derlin-2 Rabbit anti-Mouse Polyclonal (aa191-219) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Mouse Polyclonal (aa191-219) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Mouse Polyclonal (aa191-219) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Mouse Polyclonal (aa191-219) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Mouse Polyclonal (aa191-219) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$379
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (aa191-218) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (aa191-218) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (aa191-218) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (aa191-218) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (aa191-218) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (aa191-218) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
DERL2 / Derlin-2 Antibody - Mouse Derl2 Antibody western blot of mouse liver tissue lysates (35 ug/lane). The Derl2 antibody detected the Derl2 protein (arrow).
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DERL2 / Derlin-2 Rabbit anti-Mouse Polyclonal (aa191-219) Antibody
Mouse
WB
Unconjugated
400 µl/$393
DERL2 / Derlin-2 Antibody - DERL2 / Derlin-2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
DERL2 / Derlin-2 Antibody - DERL2 / Derlin-2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Chicken, Bovine, Rabbit, Mouse, Guinea pig, Rat, Bat, Gibbon, Chimpanzee, Orangutan, Human, Monkey
WB
HRP Conjugated
100 µl/$469
DERL2 / Derlin-2 Antibody - DERL2 / Derlin-2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Guinea pig, Rat, Bat, Gibbon, Chimpanzee, Orangutan, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
DERL2 / Derlin-2 Antibody - DERL2 / Derlin-2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DERL2 / Derlin-2 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Chicken, Bovine, Rabbit, Mouse, Guinea pig, Rat, Bat, Gibbon, Chimpanzee, Orangutan, Human, Monkey
WB
FITC Conjugated
100 µl/$469
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).