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Delta-6 Desaturase / FADS2

fatty acid desaturase 2

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.

Gene Name: fatty acid desaturase 2
Synonyms: FADS2, D6D, Delta-6 fatty acid desaturase, Delta-6-desaturase, FADSD6, LLCDL2, SLL0262, TU13, Delta(6) desaturase, Delta(6) fatty acid desaturase, Delta-6 desaturase, DES6, Fatty acid desaturase 2
Target Sequences: NM_004265 NP_004256.1 O95864

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).