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DEFB1 / BD-1

defensin, beta 1

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.

Gene Name:	defensin, beta 1
Synonyms:	DEFB1, BD1, Beta-defensin 1, BD-1, Beta Defensin 1, DEFB-1, DEFB101, Defensin, beta 1, Defensin beta, HBD-1, Beta-defensin-1, HBD1
Target Sequences:	NM_005218 NP_005209.1 P60022

Publications (2)

Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo. L A Ochoa-Ramírez, D S Becerra-Loaiza, S P Díaz-Camacho, V F Muñoz-Estrada, E R Ríos-Burgueño, E Prado-Montes de Oca, H Rangel-Villalobos, J S Velarde-Félix. Clinical and experimental dermatology. 2019 April;44:277-282. [Full Text Article] [PubMed:29923320]

Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract. Becknell B, Spencer JD, Carpenter AR, Chen X, Singh A, Ploeger S, Kline J, Ellsworth P, Li B, Proksch E, Schwaderer AL, Hains DS, Justice SS, McHugh KM. PloS one. 2013 8:e77714. [Full Text Article] [PubMed:24204930] [PMC:PMC3804605] Related Antibodies: LS-C20902.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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