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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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DEFA5 / Defensin 5

defensin, alpha 5, Paneth cell-specific

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Gene Name: defensin, alpha 5, Paneth cell-specific
Synonyms: DEFA5, DEF5, Defensin, alpha 5, Defensin 5, Defensin-5, HD-5, HD5(20-94)
Target Sequences: NM_021010 NP_066290.1 Q01523

Publications (5)

1
Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. Journal of clinical pathology. 2005 58:687-94. [PubMed:15976333] [PMC:PMC1770712]
2
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:18129-34. (IHC, WB) [PubMed:16330776] [PMC:PMC1306791]
3
Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. Wehkamp J, Chu H, Shen B, Feathers RW, Kays RJ, Lee SK, Bevins CL. FEBS letters. 2006 580:5344-50. (ICC, IHC) [PubMed:16989824]
4
Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer. Jung JH, Kim HJ, Yeom J, Yoo C, Shin J, Yoo J, Kang CS, Lee C. Journal of gastroenterology. 2012 47:37-48. (WB; Human) [PubMed:22015694]
5
Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes. Kim HJ, Kang UB, Lee H, Jung JH, Lee ST, Yu MH, Kim H, Lee C. Journal of proteomics. 2012 75:2983-97. [PubMed:22178445]
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Competitive EIA (2)
Custom (7)
Sandwich (9)
Sandwich CLIA (2)
Target
DEFA5 / Defensin 5 (20)
Reactivity
Human (7)
Mouse (6)
Rat (1)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
Sample Type
Cell Culture Supernatants (2)
Cell Lysates (2)
Plasma (13)
Serum (13)
Tissue Homogenates (5)
Publications
No (20)
Showing 1-20 of 20 results

Human DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F5725
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate  $740.00
LSBio image for ELISA Kit

Mouse DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F5429
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $780.00
LSBio image for ELISA Kit

Human DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F11288
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $700.00
LSBio image for ELISA Kit

Human DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F37993
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $600.00
LSBio image for ELISA Kit

Mouse DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F20755
Sandwich
96-Well Microplate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $590.00
LSBio image for ELISA Kit

Human DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F55575
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate  $810.00
LSBio image for ELISA Kit

Human DEFA5 / Defensin 5 ELISA Kit (Competitive EIA) - LS-F27678
Competitive EIA
96-Well Strip Plate
Human
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $870.00
LSBio image for ELISA Kit

Mouse DEFA5 / Defensin 5 ELISA Kit (CLIA) - LS-F30631
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1plate  $700.00
LSBio image for ELISA Kit

Human DEFA5 / Defensin 5 ELISA Kit (CLIA) - LS-F30110
Sandwich CLIA
12 x 8-Well Microstrips
Human
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1plate  $700.00
LSBio image for ELISA Kit

Chicken DEFA5 / Defensin 5 ELISA Kit (Custom ELISA) - LS-F43198
Custom
96-Well Strip Plate
Chicken
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Guinea pig DEFA5 / Defensin 5 ELISA Kit (Custom ELISA) - LS-F43200
Custom
96-Well Strip Plate
Guinea pig
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Monkey DEFA5 / Defensin 5 ELISA Kit (Custom ELISA) - LS-F43202
Custom
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Rabbit DEFA5 / Defensin 5 ELISA Kit (Custom ELISA) - LS-F43203
Custom
96-Well Strip Plate
Rabbit
0.625 - 40 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Sheep DEFA5 / Defensin 5 ELISA Kit (Custom ELISA) - LS-F43205
Custom
96-Well Strip Plate
Sheep
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
1plate  $730.00
LSBio image for ELISA Kit

Porcine DEFA5 / Defensin 5 ELISA Kit (Custom ELISA) - LS-F43206
Custom
96-Well Strip Plate
Porcine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Rat DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F40410
Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $590.00
LSBio image for ELISA Kit

Mouse DEFA5 / Defensin 5 ELISA Kit (Competitive EIA) - LS-F28906
Competitive EIA
96-Well Strip Plate
Mouse
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $870.00
LSBio image for ELISA Kit

Mouse DEFA5 / Defensin 5 ELISA Kit (Custom ELISA) - LS-F18352
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1plate  $700.00
LSBio image for ELISA Kit

Human DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F33772
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $790.00
LSBio image for ELISA Kit

Mouse DEFA5 / Defensin 5 ELISA Kit (Sandwich ELISA) - LS-F33773
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $790.00
LSBio image for ELISA Kit
Showing 1-20 of 20 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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