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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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DEFA5 / Defensin 5

defensin, alpha 5, Paneth cell-specific

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Gene Name: defensin, alpha 5, Paneth cell-specific
Synonyms: DEFA5, DEF5, Defensin, alpha 5, Defensin 5, Defensin-5, HD-5, HD5(20-94)
Target Sequences: NM_021010 NP_066290.1 Q01523

Publications (5)

1
Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. Journal of clinical pathology. 2005 58:687-94. [PubMed:15976333] [PMC:PMC1770712]
2
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:18129-34. (IHC, WB) [PubMed:16330776] [PMC:PMC1306791]
3
Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. Wehkamp J, Chu H, Shen B, Feathers RW, Kays RJ, Lee SK, Bevins CL. FEBS letters. 2006 580:5344-50. (ICC, IHC) [PubMed:16989824]
4
Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer. Jung JH, Kim HJ, Yeom J, Yoo C, Shin J, Yoo J, Kang CS, Lee C. Journal of gastroenterology. 2012 47:37-48. (WB; Human) [PubMed:22015694]
5
Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes. Kim HJ, Kang UB, Lee H, Jung JH, Lee ST, Yu MH, Kim H, Lee C. Journal of proteomics. 2012 75:2983-97. [PubMed:22178445]
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Viewing 1-25 of 47 items
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 8C8] to Human DEFA5 / Defensin 5
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   2.35mg/ml   $425.00
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 8C8] (IgG2b) to Human DEFA5 / Defensin 5
Human
IF, IHC, IHC-P, WB
Biotin Conjugated
100µl   $365.00
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 8C8] (IgG2b) to Human DEFA5 / Defensin 5
Human
IF, IHC, IHC-P, WB
DY650 Conjugated
100µl   $365.00
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 8C8] (IgG2b) to Human DEFA5 / Defensin 5
Human
IF, IHC, IHC-P, WB
DY488 Conjugated
100µl   $365.00
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 8C8] (IgG2b) to Human DEFA5 / Defensin 5
Human
IF, IHC, IHC-P, WB
DY550 Conjugated
100µl   $365.00
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal (IgG2b) to Human DEFA5 / Defensin 5
Human
IF, IHC, IHC-P, WB
Unconjugated
50µl   2.35mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human DEFA5 / Defensin 5
Human
ELISA, WB
Unconjugated
100µg   $755.00
Select
Mouse Monoclonal (IgG2a) to Rabbit DEFA5 / Defensin 5
Rabbit
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $950.00
Select
Rabbit Polyclonal (IgG) to Human DEFA5 / Defensin 5
Human
ELISA, WB
Unconjugated
100µl   $725.00
Select
Mouse Monoclonal [clone R3] (IgG2a) to Rabbit DEFA5 / Defensin 5
Rabbit
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $1,290.00
Select
Mouse Monoclonal [clone R3] (IgG2a) to Human DEFA5 / Defensin 5
Human
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated, Concentrated
100µg   $935.00
Select
Mouse Monoclonal (IgG2b) to Human DEFA5 / Defensin 5
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $950.00
Select
Mouse Monoclonal [clone R3] (IgG2a) to Rabbit DEFA5 / Defensin 5
Rabbit
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $635.00
Select
Mouse Monoclonal (IgG2b) to Human DEFA5 / Defensin 5
Human
IHC, IHC-Fr, RIA, WB
Unconjugated
0.5mg   $1,980.00
Select
Mouse Monoclonal [clone 8C8] (IgG2b) to Human DEFA5 / Defensin 5
Human
IHC, IHC-Fr, WB
Unconjugated
100µg   $635.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
Unconjugated
20µl   1mg/ml   $205.00; 100µl   1mg/ml   $255.00; 200µl   1mg/ml   $355.00; 1ml   1mg/ml   $530.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
HRP Conjugated
100µl   0.5mg/ml   $285.00; 200µl   0.5mg/ml   $345.00; 1ml   0.5mg/ml   $680.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
Biotin Conjugated
100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $315.00; 1ml   0.5mg/ml   $575.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
FITC Conjugated
100µl   0.5mg/ml   $275.00; 200µl   0.5mg/ml   $325.00; 1ml   0.5mg/ml   $635.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
Cy3 Conjugated
100µl   0.1mg/ml   $355.00; 200µl   0.1mg/ml   $445.00; 1ml   0.1mg/ml   $1,050.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
PE Conjugated
100µl   0.1mg/ml   $245.00; 200µl   0.1mg/ml   $285.00; 1ml   0.1mg/ml   $475.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
APC, Cy7 Conjugated
100µl   0.1mg/ml   $385.00; 200µl   0.1mg/ml   $475.00; 1ml   0.1mg/ml   $1,185.00
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, IP, WB
APC Conjugated
100µl   0.1mg/ml   $275.00; 200µl   0.1mg/ml   $315.00; 1ml   0.1mg/ml   $590.00
Select
Mouse Monoclonal (IgG2b) to Human DEFA5 / Defensin 5
Human
IHC, IHC-P
Unconjugated
100µl   $605.00
Select
Mouse Monoclonal (IgG) to Human DEFA5 / Defensin 5
Human
ICC, WB
Biotin Conjugated
200µl   0.5mg/ml   $375.00

Viewing 1-25 of 47 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).