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Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
Gene Name: | differentially expressed in FDCP 6 homolog (mouse) |
Synonyms: | DEF6, DEF-6, IBP, SLAT, SWAP70L, IRF4-binding protein |
Target Sequences: | NM_022047 NP_071330.3 Q9H4E7 |
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