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DEDD

death effector domain containing

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.

Gene Name:	death effector domain containing
Synonyms:	DEDD, CASP8IP1, DEDPro1, DEDD1, DEFT, FLDED-1, FLDED1, KE05
Target Sequences:	AK001497 IPI00004539.1 O75618

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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