DDX58 / RIG-1 / RIG-I

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

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Proteins (6)

Type

Over-Expression Lysate (1)

Recombinant (5)

Target

DDX58 / RIG-1 / RIG-I (6)

Publications

No (6)

Tag

GST (1)

His (1)

His, N-Terminal (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Mouse DDX58 / RIG-1 / RIG-I Protein (Recombinant His, N-Terminal) (Met1-Gln211) - LS-G13962

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

28.4 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71497

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.4 kDa

Price:

20 µg/$1,107

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant His, N-Terminal) (Asp550-Phe776) - LS-G13959

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant His) (aa1-430) - LS-G20665

Source:

E. coli

Tag:

His

Molecular Weight:

53.3 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant GST) (Full Length) - LS-G32902

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

133 kDa

Price:

10 µg/$479; 25 µg/$670

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DDX58 / RIG-1 / RIG-I Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114035

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.4 kDa

Price:

100 µg/$710

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