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DDX50

DEAD (Asp-Glu-Ala-Asp) box polypeptide 50

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined.

Gene Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Family/Subfamily: DEAD box protein
Synonyms: DDX50, DEAD box protein 50, GUB, Gu-beta, Mcdrh, Nucleolar protein Gu2, RH-II/GuB, RNA helicase II/Gu beta, GU2
Target Sequences: NM_024045 NP_076950.1 Q9BQ39

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Proteins (4)
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DDX50 (4)
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GST (1)
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293T Cells (1)
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Wheat Germ Extract (1)
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DDX50 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
82.4 kDa
100 µg/$494
DDX50 Protein - 12.5% SDS-PAGE of human DDX50 stained with Coomassie Blue
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Wheat Germ Extract
GST
109 kDa
10 µg/$479; 25 µg/$670
DDX50 Protein - Purified recombinant protein DDX50 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
82.4 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
82.4 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).