DDX5

DEAD (Asp-Glu-Ala-Asp) box helicase 5

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

DDX5 (4)

Publications

No (4)

Tag

10His, N-terminus + Myc, C-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Purification

Purified (1)

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Human DDX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77884

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69 kDa

Price:

20 µg/$150

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Human DDX5 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G136993

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

74.1 kDa

Price:

1 mg/$1,486; 100 µg/$451; 20 µg/$339

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Human DDX5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66513

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69 kDa

Price:

20 µg/$1,107

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DDX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100283

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69 kDa

Price:

100 µg/$494

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