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DDX / AKR1C3

aldo-keto reductase family 1, member C3

DDX / AKR1C3 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Gene Name: aldo-keto reductase family 1, member C3
Synonyms: AKR1C3, 3-alpha-HSD type 2, 17-beta-HSD 5, 3-alpha-HSD type II, brain, DD3, DDH1, DDX, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase X, DD-3, HA1753, HAKRe, HAKRB, HSD17B5, KIAA0119, Kia0119, Prostaglandin F synthase, PGFS, Truncated aldoketo reductase a, HluPGFS, Indanol dehydrogenase
Target Sequences: AF110411 IPI00031381.1 P42330

Publications (2)

1
Effect of Tahiti lime (Citrus latifolia) juice on the Production of the PGF2a/PGE2 and Pro-Inflammatory Cytokines involved in Menstruation. Thaiane Robeldo , Edione Fatima Canzi, Priscila Maria de Andrade , Jhonne Pedro Pedotte Santana, Felipe Roberti Teixeira, Valentine Spagnol, Beatriz Helena Lameiro Noronha Sales Maia, Maristela Carbol, Erika Gonçalves Caneira, Maria Fátima das Graças Fernandes Da Silva, Ricardo Carneiro Borra. Scientific reports. 2020 Apr;10:7063. [Full Text Article] [PubMed:32341436] [PMC:PMC7184590]
2
Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. Kuhn E, Ayhan A, Shih IeM, Seidman JD, Kurman RJ. European journal of cancer (Oxford, England : 1990). 2013 Dec;49:3839-49. [Full Text Article] [PubMed:24012099] Related Antibodies: LS-B2295.

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Antibodies (37)
Primary (37)
DDX / AKR1C3 (37)
Human (37)
Mouse (2)
Rat (3)
Bovine (3)
Chimpanzee (3)
Monkey (3)
Orangutan (3)
IHC (14)
IHC-P (4)
WB (37)
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ELISA (17)
IF (5)
Peptide-ELISA (3)
rabbit (35)
mouse (1)
goat (1)
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IHCPlus (2)
IgG (29)
polyclonal pc (37)
APC Conjugated (3)
Azide-free (2)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (19)
aa10-36 (7)
aa107-135 (7)
aa97-146 (4)
160-240 aa, Internal (1)
aa1-323 (1)
aa191-240 (1)
aa311-323 (1)
No (36)
Yes (1)
DDX / AKR1C3 Antibody - Anti-AKR1C3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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DDX / AKR1C3 Goat anti-Human Polyclonal (aa311-323) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
DDX / AKR1C3 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DDX / AKR1C3 Antibody - Western blot of extracts of Jurkat cell line, using AKR1C3 antibody.
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
DDX / AKR1C3 Antibody - 1:100 staining mouse spleen tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DDX / AKR1C3 Antibody - Immunohistochemistry of paraffin-embedded human rectal cancer using antibody at 1:100 dilution.
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa1-323) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
DDX / AKR1C3 Antibody - Immunohistochemistry of paraffin-embedded rat heart using AKR1C3 antibody at dilution of 1:100 (40x lens).
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
DDX / AKR1C3 Antibody
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$332
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa107-135) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa107-135) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa107-135) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa107-135) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa107-135) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa107-135) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa10-36) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa10-36) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
Select
DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa10-36) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa10-36) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
Select
DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa10-36) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa10-36) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
DDX / AKR1C3 Antibody - AKR1C3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa107-135) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DDX / AKR1C3 Antibody - Immunofluorescence analysis of NIH/3T3 cells using AKR1C3 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
DDX / AKR1C3 Antibody - AKR1C3 Antibody western blot of K562 cell line lysates (35 ug/lane). The AKR1C3 antibody detected the AKR1C3 protein (arrow).
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (aa10-36) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
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DDX / AKR1C3 Rabbit anti-Human Polyclonal (160-240 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DDX / AKR1C3 Antibody - Western blot analysis of extracts from COLO cells and HeLa cells, using AKR1C3 antibody.
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DDX / AKR1C3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).