Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
In melanocytes, D-dopachrome tautomerase (DDT) converts D-dopachrome into 5, 6-dihydroxyindole. The amino acid sequence of DDT is 33% homologous with that of macrophage migration inhibitory factor (MIF) which has the potential to catalyze D-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid and is an important cytokine for T-lymphocyte activation. Crystal structure studies have shown that DDT forms a homotrimer, while site-directed mutagenesis studies show that the N-terminal proline is important for enzymatic activity.
DDT, D-dopachrome decarboxylase, D-dopachrome tautomerase, DDCT, Phenylpyruvate tautomerase II