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DDR2

discoidin domain receptor tyrosine kinase 2

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Gene Name: discoidin domain receptor tyrosine kinase 2
Family/Subfamily: Protein Kinase , DDR/TKT
Synonyms: DDR2, CD167b antigen, Discoidin domain receptor 2, Hydroxyaryl-protein kinase, MIG20a, Tyrosine-protein kinase TYRO10, NTRKR3, TYRO10, Tyrosylprotein kinase
Target Sequences: NM_006182 NP_006173.2 Q16832

Publications (5)

1
Region and cell-type resolved quantitative proteomic map of the human heart. Doll S, Dreßen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M. Nature communications. 2017 November;8:1469. (Human) [Full Text Article] [PubMed:29133944] [PMC:PMC5684139] Related Antibodies: LS-C99151.
2
Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Genes & development. 2018 February;32:244-257. [Full Text Article] [PubMed:29483153] [PMC:PMC5859966] Related Antibodies: LS-C164363.
3
Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display. Travis J Antes, Ryan C Middleton, Kristin M Luther, Takeshi Ijichi, Kiel A Peck, Weixin Jane Liu, Jackie Valle, Antonio K Echavez, Eduardo Marbán. Journal of nanobiotechnology. 2018 Aug;16:61. [Full Text Article] [PubMed:30165851] [PMC:PMC6116387] Related Antibodies: LS-C255960.
4
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of PDGF Signaling. Tariq Hamid, Yuanyuan Xu, Mohamed Ameen Ismahil, Gregg Rokosh, Miki Jinno, Guihua Zhou, Qiongxin Wang, Sumanth D Prabhu. JACC. Basic to translational science. 2022 May;7:465-483. [Full Text Article] [PubMed:35663630] [PMC:PMC9156441] Related Antibodies: LS-C255961.
5
The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Fatma F Mohamed, Chunxi Ge, Randy T Cowling, Daniel Lucas, Shawn A Hallett, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Renny T Franceschi. Bone research. 2022 February;10:11. [Full Text Article] [PubMed:35140200] [PMC:PMC8828874] Related Antibodies: LS-B15752.
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☰ Filters
Products
Proteins (21)
Over-Expression Lysate (6)
Recombinant (15)
DDR2 (21)
No (21)
6His, C-terminus (2)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
Fc (2)
GST (1)
GST, N-terminus (1)
His (1)
His,C-terminus (2)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (8)
Human (13)
Mouse (3)
Rat (2)
293T Cells (3)
Baculovirus (1)
E. coli (1)
HEK 293 Cells (8)
Human Cells (4)
Mammalian Cells (1)
Sf9 Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (8)
DDR2 Protein - Purified recombinant protein DDR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
94.3 kDa
20 µg/$1,107
DDR2 Protein - Purified recombinant protein DDR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
94.3 kDa
20 µg/$1,107
DDR2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
44.1 kDa
100 µg/$721
Select
Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
77.1 kDa
50 µg/$707
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
69.4 kDa
100 µg/$721
DDR2 Protein - Recombinant  Discoidin Domain Receptor Family, Member 2 By SDS-PAGE
Select
E. coli
His-T7
31.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
DDR2 Protein - 12.5% SDS-PAGE of human DDR2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
123.1 kDa
2 µg/$439
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.5kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.5 kDa
10 µg/$266; 50 µg/$339
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44 kDa
100 µg/$721
DDR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
96.74 kDa
100 µg/$710
DDR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
96.74 kDa
100 µg/$494
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.9 kDa
50 µg/$483
DDR2 Protein
Select
Sf9 Cells
DDK,C-terminus
44.7 kDa
20 µg/$677
DDR2 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
45 kDa
20 µg/$1,107
DDR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
96.74 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
96.74 kDa
20 µg/$215
DDR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
96.74 kDa
20 µg/$150
DDR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
96.74 kDa
100 µg/$494
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
69.5 kDa
100 µg/$721
Viewing 1-21 of 21 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).