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DDOST / OST48
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDOST / OST48 is a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
| Gene Name: | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) |
| Synonyms: | DDOST, AGE-R1, AGER1, CDG1R, DDOST 48 kDa subunit, KIAA0115, OST48, OST, OKSWcl45 |
| Target Sequences: | NM_005216 NP_005207.2 P39656 |
Publications (1)
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