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DDH / AKR1C1
aldo-keto reductase family 1, member C1
DDH / AKR1C1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
| Gene Name: | aldo-keto reductase family 1, member C1 |
| Synonyms: | AKR1C1, 2-ALPHA-HSD, 20-alpha-HSD, Aldo-keto reductase C, Bile acid binding protein, Chlordecone reductase homolog, DDH1, Dihydrodiol dehydrogenase 2, DD1, DDH, Dihydrodiol dehydrogenase 1/2, DD1/DD2, Dihydrodiol dehydrogenase 1, H-37, HAKRC, HBAB, Indanol dehydrogenase, MBAB |
| Target Sequences: | NM_001353 NP_001344.2 Q04828 |
Publications (2)
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