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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DDC / DOPA Decarboxylase

dopa decarboxylase (aromatic L-amino acid decarboxylase)

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene Name: dopa decarboxylase (aromatic L-amino acid decarboxylase)
Family/Subfamily: Carboxy-lyase , Not assigned-Other
Synonyms: DDC, AADC, DOPA decarboxylase
Target Sequences: NM_000790 NP_000781.1 P20711

Publications (1)

1
Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages. Gratz MJ, Stavrou S, Kuhn C, Hofmann S, Hermelink K, Heidegger H, Hutter S, Mayr D, Mahner S, Jeschke U, Vattai A. Endocrine connections. 2018 May;7:727-738. (Human) [Full Text Article] [PubMed:29686031] [PMC:PMC5958746] Related Antibodies: LS-B10123.

Filtered by: None
Type
Over-Expression Lysate (4)
Recombinant (8)
Target
DDC / DOPA Decarboxylase (12)
Tag
GST (1)
GST,N-terminus (1)
His (4)
Myc + DDK (6)
Species
Human (9)
Mouse (1)
Source
293T Cells (2)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purification
Purified (4)
Low Endotoxin Level
Low endotoxin level (1)
Publications
No (12)
Showing 1-12 of 12 results

Human DDC / DOPA Decarboxylase Protein (Recombinant His) - LS-G489
E. coli
His
100µg 1mg/ml  $315.00; 0.5mg 1mg/ml  $695.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human DDC / DOPA Decarboxylase Protein (Recombinant Myc + DDK) (Full Length) - LS-G64985
HEK 293 Cells
Myc + DDK
53.7 kDa
20µg  $890.00
Purified recombinant protein DDC was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Human DDC / DOPA Decarboxylase Protein (Recombinant Myc + DDK) (Full Length) - LS-G64986
HEK 293 Cells
Myc + DDK
53.7 kDa
20µg  $890.00
Purified recombinant protein DDC was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Human DDC / DOPA Decarboxylase Protein (Recombinant GST) (Full Length) - LS-G28172
Wheat Germ Extract
GST
78.43 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human DDC stained with Coomassie Blue

Human DDC / DOPA Decarboxylase Protein (Recombinant His) (aa200-420) - LS-G25745
E. coli
His
28.9 kDa
10µg  $275.00; 50µg  $455.00; 100µg  $605.00; 200µg  $875.00; 1mg  $2,265.00; 500µg  $1,005.00
Recombinant Dopa Decarboxylase By SDS-PAGE

Human DDC / DOPA Decarboxylase Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G74587
293T Cells
Myc + DDK
53.7 kDa
20µg  $195.00

Human DDC / DOPA Decarboxylase Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G74588
293T Cells
Myc + DDK
53.7 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human DDC / DOPA Decarboxylase Protein (Recombinant GST,N-terminus) (aa371-480) - LS-G58310
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human DDC / DOPA Decarboxylase Protein (Recombinant His) - LS-G17632
E. coli
His
5µg  $195.00; 20µg  $255.00; 1mg  $2,850.00

DDC / DOPA Decarboxylase Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G99155
HEK 293 Cells
Myc + DDK
53.7 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Mouse DDC / DOPA Decarboxylase Protein (Recombinant His) (Met1-Glu480) - LS-G98125
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
55.2 kDa
20µg  $415.00; 100µg  $950.00

DDC / DOPA Decarboxylase Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G119790
HEK 293 Cells
Myc + DDK
53.7 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-12 of 12 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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