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DDC / DOPA Decarboxylase

dopa decarboxylase (aromatic L-amino acid decarboxylase)

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene Name: dopa decarboxylase (aromatic L-amino acid decarboxylase)
Family/Subfamily: Carboxy-lyase , Not assigned-Other
Synonyms: DDC, AADC, DOPA decarboxylase
Target Sequences: NM_000790 NP_000781.1 P20711

Publications (2)

1
Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages. Gratz MJ, Stavrou S, Kuhn C, Hofmann S, Hermelink K, Heidegger H, Hutter S, Mayr D, Mahner S, Jeschke U, Vattai A. Endocrine connections. 2018 May;7:727-738. (Human) [Full Text Article] [PubMed:29686031] [PMC:PMC5958746] Related Antibodies: LS-B10123.
2
Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma. Yan Yan, Jiahao Pan, Yonghua Chen, Wei Xing, Qiang Li, Dongyin Wang, Xiaoshuang Zhou, Jingdun Xie, Changhong Miao, Yunfei Yuan, Weian Zeng, Dongtai Chen. Cancer communications (London, England). 2020 December;40:694-710. [Full Text Article] [PubMed:33017522] [PMC:PMC7743025]

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Proteins (12)
Over-Expression Lysate (4)
Recombinant (8)
DDC / DOPA Decarboxylase (12)
No (12)
GST (1)
GST, N-terminus (1)
His (3)
His,C-terminus (1)
Myc-DDK (Flag) (6)
Human (9)
Mouse (1)
293T Cells (2)
Baculovirus (1)
E. coli (2)
HEK 293 Cells (4)
Insect Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (2)
DDC / DOPA Decarboxylase Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
DDC / DOPA Decarboxylase Protein - Purified recombinant protein DDC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.7 kDa
20 µg/$1,107
DDC / DOPA Decarboxylase Protein - Purified recombinant protein DDC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.7 kDa
20 µg/$1,107
DDC / DOPA Decarboxylase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
53.7 kDa
20 µg/$150
DDC / DOPA Decarboxylase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.7 kDa
20 µg/$215
DDC / DOPA Decarboxylase Protein - Recombinant Dopa Decarboxylase By SDS-PAGE
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E. coli
His
28.9 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
DDC / DOPA Decarboxylase Protein - 12.5% SDS-PAGE of human DDC stained with Coomassie Blue
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Wheat Germ Extract
GST
78.43 kDa
10 µg/$479; 25 µg/$670
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Insect Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
55 kDa
50 µg/$1,007
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Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
55.2 kDa
100 µg/$843
DDC / DOPA Decarboxylase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
53.7 kDa
100 µg/$494
DDC / DOPA Decarboxylase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
53.7 kDa
100 µg/$710
Viewing 1-12 of 12 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).