DDB1

damage-specific DNA binding protein 1, 127kDa

Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

DDB1 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human DDB1 Protein (Recombinant GST) (Full Length) - LS-G28170

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

153.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DDB1 Protein (Recombinant GST, N-terminus) (aa1044-1140) - LS-G58306

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DDB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81224

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.8 kDa

Price:

20 µg/$150

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DDB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118311

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.8 kDa

Price:

100 µg/$494

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