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DCX / Doublecortin

doublecortin

DCX / Doublecortin is a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: doublecortin
Synonyms: DCX, DBCN, Doublecortin, Doublin, Doublecortex, Lis-X, SCLH, LISX, XLIS, Lissencephalin-X
Target Sequences: NM_000555 NP_000546.2 O43602

☰ Filters
Products
Antibodies (73)
Primary (73)
DCX / Doublecortin (73)
Human (61)
Mouse (46)
Rat (27)
Bat (1)
Bovine (3)
Chicken (3)
Chimpanzee (6)
Dog (1)
Gibbon (6)
Hamster (1)
Horse (4)
Monkey (4)
Pig (2)
Rabbit (1)
IHC (25)
IHC-P (5)
WB (60)
Flo (4)
ELISA (26)
ICC (4)
IF (16)
IP (2)
Peptide-ELISA (8)
rabbit (60)
mouse (9)
goat (4)
Product Group
IHCPlus (1)
IgG (46)
IgG1 (4)
IgG1,k (1)
IgG2a (2)
IgG2a,k (1)
monoclonal mc (8)
polyclonal pc (64)
recombinant monoclonal rmc (1)
01 (1)
1G12 (1)
2G5 (2)
3E1 (1)
OTI4A3 (2)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (6)
Carrier-free (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (2)
Preservative Free (2)
Unconjugated (49)
aa1-366 (8)
Ser128 (7)
aa254-303 (4)
aa362-411 (4)
180-260 aa (1)
Amino Acid: 362-411 (1)
Amino Acids 69-81 (1)
Internal Region (1)
Lys292 (1)
aa206-255 (1)
aa232-242 (1)
aa284-297 (1)
aa346-395 (1)
p297 (1)
p376 (1)
pSer334 (1)
pSer376 (1)
pSer378 (1)
No (73)
DCX / Doublecortin Antibody - DCX / Doublecortin antibody Negative Control showing staining of paraffin embedded Human Cerebellum, with no primary antibody.
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DCX / Doublecortin Goat anti-Human Polyclonal (aa232-242) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µg/$503
DCX / Doublecortin Antibody - Rat brain neural cultures stained with DCX / Doublecortin antibody (green), chicken polyclonal antibody to GFAP (red) and DNA (blue). The DCX / Doublecortin antibody antibody reveals strong cytoplasmic staining in a population of small developing neurons. These cells are often found in small clumps as in these cultures, as in this example. Note that they are not positive for MAP2, which is characteristic of more mature neurons, and that the mature neuron shown is negative for DCX / Doublecortin antibody. This DCX antibody is therefore an excellent marker of developing neuronal cells.
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DCX / Doublecortin Mouse anti-Human Monoclonal (3E1) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
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DCX / Doublecortin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IF
Unconjugated
100 µl/$665
DCX / Doublecortin Antibody - Anti-DCX / Doublecortin antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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DCX / Doublecortin Mouse anti-Human Monoclonal (2G5) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
DCX / Doublecortin Antibody - DCX / Doublecortin antibody immunofluorescence analysis of paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (5ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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DCX / Doublecortin Goat anti-Mouse Polyclonal (aa284-297) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
DCX / Doublecortin Antibody - Antibody Immunofluorescence analysis of paraformaldehyde fixed NIH3T3 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (5ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (
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DCX / Doublecortin Goat anti-Mouse Polyclonal (Internal Region) Antibody
Mouse
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
DCX / Doublecortin Antibody - Doublecortin Antibody in Immunohistochemistry (IHC)
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DCX / Doublecortin Mouse anti-Human Monoclonal (Amino Acid: 362-411) (2G5) Antibody
Mouse, Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$503
DCX / Doublecortin Antibody - 1:200 staining mouse brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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DCX / Doublecortin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DCX / Doublecortin Antibody - Anti-DCX mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DCX.
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DCX / Doublecortin Mouse anti-Human Monoclonal (OTI4A3) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
DCX / Doublecortin Antibody - Anti-DCX mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DCX.
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DCX / Doublecortin Mouse anti-Human Monoclonal (Carrier-free) (OTI4A3) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
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DCX / Doublecortin Rabbit Recombinant Monoclonal Antibody
ICC, IHC, IP, WB
Unconjugated
10 µl/$299; 100 µl/$548
DCX / Doublecortin Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using DCX Polyclonal Antibody at dilution of 1:30(×200)
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DCX / Doublecortin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DCX / Doublecortin Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using DCX Polyclonal Antibody at dilution of 1:35(×200)
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DCX / Doublecortin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DCX / Doublecortin Antibody - Immunofluorescence of monoclonal antibody to DCX on HeLa cell . [antibody concentration 10 ug/ml]
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DCX / Doublecortin Mouse anti-Human Monoclonal (1G12) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
DCX / Doublecortin Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using antibody at dilution of 1:100.
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DCX / Doublecortin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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DCX / Doublecortin Rabbit anti-Human Polyclonal (Ser128) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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DCX / Doublecortin Rabbit anti-Human Polyclonal (Ser128) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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DCX / Doublecortin Rabbit anti-Human Polyclonal (Ser128) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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DCX / Doublecortin Rabbit anti-Human Polyclonal (Ser128) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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DCX / Doublecortin Rabbit anti-Human Polyclonal (Ser128) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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DCX / Doublecortin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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DCX / Doublecortin Mouse anti-Human Monoclonal (Preservative Free) (01) Antibody
Human
ICC, IF
Unconjugated, Preservative Free
100 µl/$412
DCX / Doublecortin Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DCX / Doublecortin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
DCX / Doublecortin Antibody - Western blot of Doublecortin antibody
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DCX / Doublecortin Rabbit anti-Human Polyclonal (180-260 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DCX / Doublecortin Antibody - Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with DCX Antibody (S128) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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DCX / Doublecortin Rabbit anti-Human Polyclonal (Ser128) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Viewing 1-25 of 73 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).