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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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DCTN1 / Dynactin 1

dynactin 1

DCTN1 / Dynactin 1 is the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Gene Name: dynactin 1
Synonyms: DCTN1, DAP-150, Dynactin subunit 1, DP-150, Dynactin 1, HMN7B, p150-glued, p135
Target Sequences: NM_023019 NP_075408.1 Q14203


DCTN1 / Dynactin 1 Antibody - Anti-DCTN1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal to Human DCTN1 / Dynactin 1
Mouse, Hamster, Horse, Human, Monkey
ICC, IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
DCTN1 / Dynactin 1 Antibody - Anti-DCTN1 / Dynactin 1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ICC, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
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Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg   $325.00
DCTN1 / Dynactin 1 Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
DCTN1 / Dynactin 1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.
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Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $285.00; 100µl   $385.00
DCTN1 / Dynactin 1 Antibody - Western blot analysis of extracts of various cell lines.
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Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
Select
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ELISA, IHC, WB
Unconjugated
100µg   $375.00
DCTN1 / Dynactin 1 Antibody - Western Blot (WB) analysis using Dynactin 1 Monoclonal Antibody against A2780, TF-1, HepG2, MCF7, A431, K562 cell lysate.
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Mouse Monoclonal to Human DCTN1 / Dynactin 1
Mouse, Bovine, Pig, Human
IF, WB
Unconjugated
50µl   1mg/ml   $275.00; 100µl   1mg/ml   $345.00
DCTN1 / Dynactin 1 Antibody - Western blot detection of DCTN1 in A2780,TF-1,HepG2,MCF7,A431&K562 cell lysate(1:1000 diluted).
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Mouse Monoclonal to Human DCTN1 / Dynactin 1
Mouse, Bovine, Pig, Human
ICC, WB
Unconjugated
100µl   $385.00
Select
Mouse Monoclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ELISA, WB
Unconjugated
100µg   $590.00
DCTN1 / Dynactin 1 Antibody - Western blot of extracts of Jurkat cell lines, using DCTN1 antibody.
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Rabbit Polyclonal to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
DCTN1 / Dynactin 1 Antibody - Detection limit for recombinant GST tagged DCTN1 is 0.1 ng/ml as a capture antibody.
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Mouse Monoclonal [clone 1E12] (IgG1,l) to Human DCTN1 / Dynactin 1
Human
ELISA, WB
Unconjugated
100µg   $365.00
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Sheep Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg   $325.00
DCTN1 / Dynactin 1 Antibody - Western blot detection of Dynactin 1 in K562, MCF7, 293T and Hela cell lysates using Dynactin 1 mouse mAb (1:500 diluted). Predicted band size: 150KDa. Observed band size: 150KDa.
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Mouse Monoclonal (IgG2b) to Human DCTN1 / Dynactin 1
Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
DCTN1 / Dynactin 1 Antibody - Western blot detection of Dynactin 1 in K562, MCF7, 293T and HeLa cell lysates using Dynactin 1 mouse monoclonal antibody (1:500 dilution). Predicted band size: 150KDa. Observed band size: 150KDa.
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Mouse Monoclonal to Human DCTN1 / Dynactin 1
Human
IP, WB
Unconjugated
100µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Human
IP, WB
Unconjugated
100µl   1mg/ml   $405.00
Select
Mouse Monoclonal [clone 3D5-C6-D5] (IgG1) to Human DCTN1 / Dynactin 1
Human
WB
Unconjugated
100µg   $395.00
Select
Rabbit Polyclonal to Drosophila DCTN1 / Dynactin 1
Drosophila
IHC
Unconjugated
100µl   $285.00; 200µl   $345.00
Select
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
DCTN1 / Dynactin 1 Antibody - Western blot analysis of Dynactin 1 expression in HeLa (A); HepG2 (B); mouse brain (C); mouse lung (D) whole cell lysates.
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Rabbit Polyclonal to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
WB
Unconjugated
50µl   1mg/ml   $255.00; 100µl   1mg/ml   $295.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
IP
Unconjugated
100µl   1mg/ml   $405.00
DCTN1 / Dynactin 1 Antibody - DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $385.00
DCTN1 / Dynactin 1 Antibody - DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
DCTN1 / Dynactin 1 Antibody - DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl   1mg/ml   $405.00
DCTN1 / Dynactin 1 Antibody - DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100µl   1mg/ml   $405.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).