Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Reasearch Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

DCTN1 / Dynactin 1

dynactin 1

DCTN1 / Dynactin 1 is the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Gene Name: dynactin 1
Synonyms: DCTN1, DAP-150, Dynactin subunit 1, DP-150, Dynactin 1, HMN7B, p150-glued, p135
Target Sequences: NM_023019 NP_075408.1 Q14203

Filtered by: None
Target
DCTN1 / Dynactin 1 (24)
Reactivity
Human (23)
Mouse (16)
Rat (13)
Bat (4)
Bovine (5)
Chimpanzee (3)
Dog (4)
Drosophila (1)
Gibbon (3)
Guinea pig (4)
Hamster (1)
Horse (5)
Monkey (5)
Orangutan (3)
Pig (5)
Rabbit (4)
Application
IHC (12)
IHC-P (3)
WB (22)
ELISA (7)
ICC (3)
IF (3)
IP (3)
Peptide-ELISA (1)
Host
rabbit (18)
mouse (4)
goat (1)
sheep (1)
Isotype
IgG (13)
IgG1,l (1)
Clonality
monoclonal mc (4)
polyclonal pc (20)
Clone
1E12 (1)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (21)
Epitope
aa967-1016 (4)
Internal (1)
N-Terminus (1)
aa1082-1270 (1)
aa1084-1278 (1)
aa1100-1150 (1)
aa120-170 (1)
aa1216-1278 (1)
aa1228-1278 (1)
aa1266-1278 (1)
Publications
No (24)
Showing 1-24 of 24 results

IHC-plus™ DCTN1 / Dynactin 1 Antibody (aa1266-1278) LS-B2275
Goat Polyclonal to Human DCTN1 / Dynactin 1
Mouse, Hamster, Horse, Human, Monkey
ICC, IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-DCTN1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
DCTN1 / Dynactin 1 antibody immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

IHC-plus™ DCTN1 / Dynactin 1 Antibody (aa1216-1278) LS-B10901
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ICC, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-DCTN1 / Dynactin 1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa using DCTN1 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with alpha-tubulin antibody (Red) at 1:2000.

DCTN1 / Dynactin 1 Antibody (aa120-170) LS-C94057
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg  $325.00

DCTN1 / Dynactin 1 Antibody LS-C806243
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

DCTN1 / Dynactin 1 Antibody (aa1084-1278) LS-C377476
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human brain tissue using antibody at 1:100 dilution.

DCTN1 / Dynactin 1 Antibody LS-C401588
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.4mg/ml  $205.00; 60µl 0.4mg/ml  $235.00; 120µl 0.4mg/ml  $295.00; 200µl 0.4mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using DCTN1 Polyclonal Antibody at dilution of 1:60.
Immunohistochemistry of paraffin-embedded Human gastric cancer using DCTN1 Polyclonal Antibody at dilution of 1:60.

DCTN1 / Dynactin 1 Antibody LS-C404881
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.6mg/ml  $205.00; 60µl 0.6mg/ml  $235.00; 120µl 0.6mg/ml  $295.00; 200µl 0.6mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human thyroid cancer using DCTN1 Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of paraffin-embedded Human gastric cancer using DCTN1 Polyclonal Antibody at dilution of 1:50.

DCTN1 / Dynactin 1 Antibody LS-C335182
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of various cell lines.
Western blot analysis of extracts of various cell lines, using DCTN1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.

DCTN1 / Dynactin 1 Antibody LS-C751779
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ELISA, IHC, WB
Unconjugated
100µg  $335.00

DCTN1 / Dynactin 1 Antibody LS-C178264
Mouse Monoclonal to Human DCTN1 / Dynactin 1
Mouse, Bovine, Pig, Human
ICC, WB
Unconjugated
100µl  $385.00
Western blot detection of DCTN1 in A2780,TF-1,HepG2,MCF7,A431&K562 cell lysate(1:1000 diluted).

DCTN1 / Dynactin 1 Antibody LS-C192753
Rabbit Polyclonal to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl  $385.00
Western blot of extracts of Jurkat cell lines, using DCTN1 antibody.

DCTN1 / Dynactin 1 Antibody (aa1082-1270) LS-C125500
Mouse Monoclonal (IgG) to Human DCTN1 / Dynactin 1
Human
ELISA, WB
Unconjugated
100µg  $590.00

DCTN1 / Dynactin 1 Antibody (clone 1E12) LS-C197028
Mouse Monoclonal [clone 1E12] (IgG1,l) to Human DCTN1 / Dynactin 1
Human
ELISA, WB
Unconjugated
100µg  $365.00
Detection limit for recombinant GST tagged DCTN1 is 0.1 ng/ml as a capture antibody.

DCTN1 / Dynactin 1 Antibody (Internal) LS-C94059
Sheep Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg  $325.00

DCTN1 / Dynactin 1 Antibody LS-C394091
Mouse Monoclonal to Human DCTN1 / Dynactin 1
Human
IP, WB
Unconjugated
100µl  $325.00
Western blot detection of Dynactin 1 in K562, MCF7, 293T and HeLa cell lysates using Dynactin 1 mouse monoclonal antibody (1:500 dilution). Predicted band size: 150KDa. Observed band size: 150KDa.
Immunoprecipitation analysis of HeLa cell lysates using Dynactin 1 mouse monoclonal antibody.

DCTN1 / Dynactin 1 Antibody (aa1228-1278) LS-C289774
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Human
IP, WB
Unconjugated
100µl 1mg/ml  $395.00

DCTN1 / Dynactin 1 Antibody (N-Terminus) LS-C144959
Rabbit Polyclonal to Drosophila DCTN1 / Dynactin 1
Drosophila
IHC
Unconjugated
100µl  $365.00

DCTN1 / Dynactin 1 Antibody LS-C765994
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

DCTN1 / Dynactin 1 Antibody LS-C482311
Rabbit Polyclonal to Human DCTN1 / Dynactin 1
Mouse, Rat, Human
WB
Unconjugated
50µl 1mg/ml  $255.00; 100µl 1mg/ml  $295.00; 200µl 1mg/ml  $375.00
Western blot analysis of Dynactin 1 expression in HeLa (A); HepG2 (B); mouse brain (C); mouse lung (D) whole cell lysates.

DCTN1 / Dynactin 1 Antibody (aa1100-1150) LS-C289771
Rabbit Polyclonal (IgG) to Human DCTN1 / Dynactin 1
Human
IP
Unconjugated
100µl 1mg/ml  $395.00

DCTN1 / Dynactin 1 Antibody (aa967-1016) LS-C151276
Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $385.00
DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DCTN1 / Dynactin 1 Antibody (aa967-1016, HRP) LS-C455414
Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $405.00
DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DCTN1 / Dynactin 1 Antibody (aa967-1016, Biotin) LS-C455009
Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $405.00
DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DCTN1 / Dynactin 1 Antibody (aa967-1016, FITC) LS-C455010
Rabbit Polyclonal to Rat DCTN1 / Dynactin 1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $405.00
DCTN1 antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-24 of 24 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).