DCLRE1C / Artemis

DNA cross-link repair 1C

Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.

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Products

Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

DCLRE1C / Artemis (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human DCLRE1C / Artemis Protein (Recombinant GST) (Full Length) - LS-G34991

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.48 kDa

Price:

2 µg/$439

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DCLRE1C / Artemis Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120966

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.3 kDa

Price:

100 µg/$710

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Human DCLRE1C / Artemis Protein (Recombinant GST, N-terminus) (aa481-577) - LS-G63095

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DCLRE1C / Artemis Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83226

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.3 kDa

Price:

20 µg/$215

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Human DCLRE1C / Artemis Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83227

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.2 kDa

Price:

20 µg/$150

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DCLRE1C / Artemis Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101830

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.2 kDa

Price:

100 µg/$494

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