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DCLK2 / DCAMKL2
doublecortin-like kinase 2
DCLK2 / DCAMKL2 is a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
| Gene Name: | doublecortin-like kinase 2 |
| Family/Subfamily: | Protein Kinase , DCAMKL |
| Synonyms: | DCLK2, CLICK-II, DCDC3, DCDC3B, CL2, CLIK2, DCAMKL2, Doublecortin-like kinase 2, CLICK2, DCK2 |
| Target Sequences: | BC032726 NP_001035350.2 Q8N568 |
![DCLK2 / DCAMKL2 Antibody - DCAMKL2 antibody [N2C2], Internal detects DCAMKL2 protein at Cytoplasm by immunofluorescent analysis. HepG2 cells were fixed in -20 100% MeOH for 5 min. DCAMKL2 protein stained by DCAMKL2 antibody [N2C2], Internal diluted at 1:500.](https://lsbio-7d62.kxcdn.com/image2/dclk2-dcamkl2-antibody-aa187-522-ls-c185753/138466_5142725.jpg)
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