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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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DCC
deleted in colorectal carcinoma
DCC is a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
| Gene Name: | deleted in colorectal carcinoma |
| Synonyms: | DCC, CRC18, Colorectal tumor suppressor, Colorectal cancer suppressor, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC, CRCR1 |
| Target Sequences: | NM_005215 NP_005206.2 P43146 |
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