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Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
Gene Name: | DBF4 homolog B (S. cerevisiae) |
Synonyms: | DBF4B, ASKL1, Dbf4-related factor 1, DRF1, Chiffon homolog B, DBF4 homolog B (S. cerevisiae), Protein DBF4 homolog B, ASK-like protein 1, CHIFB, ZDBF1B |
Target Sequences: | NM_025104 NP_079380.2 Q8NFT6 |
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