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DAZL

deleted in azoospermia-like

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: deleted in azoospermia-like
Family/Subfamily: DAZ
Synonyms: DAZL, DAZL1, DAZ-like autosomal, DAZLA, Deleted in azoospermia-like 1, SPGY-like-autosomal, DAZ homolog, DAZH, Deleted in azoospermia-like, SPGYLA
Target Sequences: NM_001351 NP_001342.2 Q92904

Publications (1)

1
Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis. Wu Y, Hu X, Li Z, Wang M, Li S, Wang X, Lin X, Liao S, Zhang Z, Feng X, Wang S, Cui X, Wang Y, Gao F, Hess RA, Han C. Scientific reports. 2016 6:20435. (WB; Human) [Full Text Article] [PubMed:26853561] [PMC:PMC4745085] Related Antibodies: LS-C188293.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).