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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DAXX

death-domain associated protein

Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activatiopn of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upopn neuronal activation asociates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV).

Gene Name: death-domain associated protein
Family/Subfamily: Apoptosis
Synonyms: DAXX, BING2, CENP-C binding protein, DAP6, Death-associated protein 6, EAP1, Fas-binding protein, HDaxx, ETS1-associated protein 1
Target Sequences: NM_001350 NP_001341.1 Q9UER7

Viewing 1-25 of 75 items
DAXX Antibody - Anti-DAXX antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal to Human DAXX
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $485.00
DAXX Antibody - Anti-DAXX antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:67.
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Rabbit Polyclonal (IgG) to Human DAXX
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
DAXX Antibody - Confocal immunofluorescence of PANC-1 cells using DAXX mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
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Mouse Monoclonal [clone 7A11] (IgG1) to Human DAXX
Human
ELISA, Flo, IF, WB
Unconjugated
100µl   1mg/ml   $345.00
DAXX Antibody - Immunohistochemical analysis of DAXX staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human DAXX
Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $245.00
DAXX Antibody - Immunofluorescence of monoclonal antibody to DAXX on HeLa cell . [antibody concentration 10 ug/ml]
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Mouse Monoclonal [clone 4C2] (IgG2b,k) to Human DAXX
Human
ELISA, IF, WB
Unconjugated
100µg   $365.00
Select
Rabbit Monoclonal (IgG) to Human DAXX
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
100µl   $530.00
DAXX Antibody - DAXX Antibody in Immunofluorescence (IF)
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Mouse Monoclonal [clone 7A11] (IgG1) to Human DAXX
Human
Flo, ICC, IF, WB
Unconjugated
100µl   $445.00
DAXX Antibody - Confocal Immunofluorescence (IF) analysis of PANC-1 cells using Daxx Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye.
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Mouse Monoclonal (IgG1) to Human DAXX
Human
ELISA, Flo, IF, WB
Unconjugated
100µl   1mg/ml   $345.00
DAXX Antibody - DAXX antibody IHC-paraffin. IHC(P): Rat Intestine Tissue.
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Rabbit Polyclonal to Human DAXX
Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100µg   $325.00
DAXX Antibody
Select
Rabbit Polyclonal (IgG) to Human DAXX
Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100µg   $435.00
DAXX Antibody
Select
Rabbit Polyclonal (IgG) to Human DAXX
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
DAXX Antibody
Select
Rabbit Polyclonal (IgG) to Human DAXX
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
DAXX Antibody - Immunocytochemistry of DAXX in HeLa cells with DAXX antibody at 10 µg/ml.
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Rabbit Polyclonal (IgG) to Human DAXX
Mouse, Human
ELISA, ICC, IF, WB
Unconjugated
0.1mg   $365.00
DAXX Antibody - Western blot of Daxx antibody
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Rabbit Polyclonal (IgG) to Human DAXX
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human DAXX
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $890.00
DAXX Antibody - DAXX Antibody in Immunofluorescence (IF)
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Mouse Monoclonal [clone DAXX-01] (IgG1) to Human DAXX
Human
ICC, IF, WB
Unconjugated
100µg   $365.00
DAXX Antibody - Formalin-fixed paraffin-embedded tissue sections of human prostate cancer (A and B) stained for Daxx expression using Polyclonal Antibody to DAXX at 1:2000. Hematoxylin-Eosin counterstain.
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Rabbit Polyclonal to Human DAXX
Rabbit, Dog, Sheep, Bovine, Rat, Pig, Horse, Human, Monkey
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
DAXX Antibody - Western blot of Daxx (D384) pAb in extracts from 293 cells.
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Rabbit Polyclonal to Human DAXX
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100µl   $345.00
DAXX Antibody - Immunohistochemistry analysis of paraffin-embedded human ovary, using Daxx (Phospho-Ser668) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human DAXX
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Mouse Monoclonal (IgG1) to Human DAXX
Human
ELISA, ICC, WB
Unconjugated
100µg   $515.00
Select
Mouse Monoclonal [clone DAXX-01] (IgG1) to Human DAXX
Human
IF, IHC-Fr, WB
Unconjugated
0.1mg   $325.00
Select
Rabbit Polyclonal (IgG) to Human DAXX
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
DAXX Antibody - Peptide - + Immunofluorescence analysis of HeLa cells, using DAXX antibody.
Select
Rabbit Polyclonal (IgG) to Human DAXX
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µg   $305.00
DAXX Antibody - Western blot of Phospho-Daxx (S668) antibody
Select
Rabbit Polyclonal (IgG) to Human DAXX
Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
DAXX Antibody - Western blot of Daxx antibody
Select
Rabbit Polyclonal (IgG) to Human DAXX
Human, Monkey
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00

Viewing 1-25 of 75 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).