DAPK3 / ZIP Kinase

death-associated protein kinase 3

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.

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Proteins (5)

Type

Recombinant (5)

Target

DAPK3 / ZIP Kinase (5)

Publications

No (5)

Tag

GST (2)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (1)

Species

Human (4)

Mouse (1)

Source

Baculovirus (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human DAPK3 / ZIP Kinase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67433

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.4 kDa

Price:

20 µg/$1,107

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Human DAPK3 / ZIP Kinase Protein (Recombinant GST, N-terminus) (aa355-454) - LS-G58295

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DAPK3 / ZIP Kinase Protein (Recombinant GST) (Met1-Arg454) - LS-G97368

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

79 kDa

Price:

50 µg/$707

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Mouse DAPK3 / ZIP Kinase Protein (Recombinant His-T7) (aa1-448) - LS-G25559

Source:

E. coli

Tag:

His-T7

Molecular Weight:

55.1 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human DAPK3 / ZIP Kinase Protein (Recombinant GST) (Full Length) - LS-G28156

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

75.57 kDa

Price:

10 µg/$479; 25 µg/$670

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