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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DAPK3 / ZIP Kinase

death-associated protein kinase 3

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.

Gene Name: death-associated protein kinase 3
Family/Subfamily: Protein Kinase , DAPK
Synonyms: DAPK3, DAP-like kinase, Dlk, MYPT1 kinase, ZIP kinase isoform, ZIP, DAP kinase 3, ZIP Kinase, ZIP-kinase, ZIPK
Target Sequences: NM_001348 NP_001339.1 O43293

Filtered By: None
Target
DAPK3 / ZIP Kinase (50)
Reactivity
Human (32)
Mouse (29)
Rat (10)
Bovine (1)
Dog (2)
Guinea pig (1)
Horse (1)
Application
IHC (23)
IHC-P (4)
WB (45)
Flo (1)
ELISA (17)
ICC (4)
IF (5)
IP (2)
Peptide-ELISA (2)
Host
rabbit (49)
mouse (1)
Isotype
IgG (35)
IgG1 (1)
Clonality
monoclonal mc (1)
polyclonal pc (49)
Clone
4H4C8 (1)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (7)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (7)
HRP Conjugated (6)
PE Conjugated (3)
Unconjugated (21)
Epitope
aa1-448 (10)
C-Terminus (8)
aa255-282 (8)
210-290 aa (2)
Internal (1)
Lys261 (1)
N-Terminus (1)
aa1-50 (1)
aa241-290 (1)
aa279-298 (1)
aa404-454 (1)
pThr265 (1)
Publications
No (50)
Showing 1-25 of 50 results

DAPK3 / ZIP Kinase Antibody (Internal) IHC-plus™ LS-B557
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-DAPK3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-DAPK3 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-DAPK3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-DAPK3 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

DAPK3 / ZIP Kinase Antibody (aa255-282) IHC-plus™ LS-B11575
Rabbit Polyclonal to Mouse DAPK3 / ZIP Kinase
Mouse
IHC IHC-P WB
Unconjugated
200µl  $425.00
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Dapk3 Antibody western blot of mouse testis tissue lysates (35 ug/lane). The Dapk3 antibody detected the Dapk3 protein (arrow).
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Dapk3 Antibody western blot of mouse testis tissue lysates (35 ug/lane). The Dapk3 antibody detected the Dapk3 protein (arrow).

DAPK3 / ZIP Kinase Antibody (aa1-448) LS-C373328
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $545.00; 10ml 0.5mg/ml  $2,160.00
Western blot of DAPK3 / ZIP Kinase antibody.
Western blot of DAPK3 / ZIP Kinase antibody.

DAPK3 / ZIP Kinase Antibody (aa1-448, Biotin) LS-C423754
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $375.00

DAPK3 / ZIP Kinase Antibody (aa1-448, Biotin) LS-C688475
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $275.00; 200µl  $315.00; 1ml  $590.00; 10ml  $2,370.00
Western blot of DAPK3 / ZIP Kinase antibody.
Western blot of DAPK3 / ZIP Kinase antibody.

DAPK3 / ZIP Kinase Antibody (aa1-448, FITC) LS-C423755
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $395.00

DAPK3 / ZIP Kinase Antibody (N-Terminus) LS-C46922
Rabbit Polyclonal to Mouse DAPK3 / ZIP Kinase
Mouse, Rat, Human
ELISA WB
Unconjugated
100µg 0.5mg/ml  $315.00

DAPK3 / ZIP Kinase Antibody (210-290 aa) LS-C381141
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Phospho-DAPK3 (T265) antibody
Western blot of Phospho-DAPK3 (T265) antibody

DAPK3 / ZIP Kinase Antibody LS-C754914
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Human
ELISA IHC IP WB
Unconjugated
100µg  $355.00

DAPK3 / ZIP Kinase Antibody (aa255-282) LS-C320742
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ELISA IHC WB
Unconjugated
200µl  $530.00

DAPK3 / ZIP Kinase Antibody (aa255-282, Biotin) LS-C259159
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

DAPK3 / ZIP Kinase Antibody (aa255-282, FITC) LS-C259160
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ELISA IHC WB
FITC Conjugated
200µl  $680.00

DAPK3 / ZIP Kinase Antibody (aa255-282, AP) LS-C255849
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ELISA IHC WB
AP Conjugated
200µl  $680.00

DAPK3 / ZIP Kinase Antibody (aa255-282, APC) LS-C255852
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ELISA IHC WB
APC Conjugated
200µl  $680.00

DAPK3 / ZIP Kinase Antibody (aa255-282, PE) LS-C259163
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ELISA IHC WB
PE Conjugated
200µl  $680.00

DAPK3 / ZIP Kinase Antibody (aa255-282, Azide-free, HRP) LS-C259161
Rabbit Polyclonal (IgG) to Mouse DAPK3 / ZIP Kinase
Mouse
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

DAPK3 / ZIP Kinase Antibody (aa241-290) LS-C117877
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using DAPK3 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HUVEC cells, using DAPK3 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using DAPK3 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HUVEC cells, using DAPK3 Antibody. The lane on the right is blocked with the synthesized peptide.

DAPK3 / ZIP Kinase Antibody LS-C754981
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Human
ELISA IF WB
Unconjugated
100µg  $375.00

DAPK3 / ZIP Kinase Antibody LS-C498664
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Mouse, Human
ELISA IF WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunofluorescent analysis of Hela cells using DAPK3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in:HepG2 whole cell lysate,Mouse brain tissue;All lanes: DAPK3 antibody at 3.4ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 53,38 kDa;Observed band size: 53 kDa;
Immunofluorescent analysis of Hela cells using DAPK3 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in:HepG2 whole cell lysate,Mouse brain tissue;All lanes: DAPK3 antibody at 3.4ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 53,38 kDa;Observed band size: 53 kDa;

DAPK3 / ZIP Kinase Antibody (210-290 aa) LS-C383079
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of DAPK3 antibody
Western blot of DAPK3 antibody

DAPK3 / ZIP Kinase Antibody (phospho-Thr265) LS-C198871
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Mouse, Rat, Human
IF Peptide-ELISA WB
Unconjugated
20µl 1mg/ml  $205.00; 50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunofluorescence analysis of A549 cells, using DAPK3 (Phospho-Thr265) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HUVEC cells, using DAPK3 (Phospho-Thr265) Antibody. The lane on the right is blocked with the phospho peptide.
Immunofluorescence analysis of A549 cells, using DAPK3 (Phospho-Thr265) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HUVEC cells, using DAPK3 (Phospho-Thr265) Antibody. The lane on the right is blocked with the phospho peptide.

DAPK3 / ZIP Kinase Antibody (clone 4H4C8) LS-C669156
Mouse Monoclonal [clone 4H4C8] (IgG1) to Human DAPK3 / ZIP Kinase
Human
ELISA Flo
Unconjugated
0.1mg  $365.00

DAPK3 / ZIP Kinase Antibody (Lys261) LS-C177758
Rabbit Polyclonal to Human DAPK3 / ZIP Kinase
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of ZIP-kinase (K261) pAb in paraffin-embedded human lung carcinoma tissue.
Western blot of ZIP-kinase (K261) pAb in extracts from HUVEC cells.
IHC of ZIP-kinase (K261) pAb in paraffin-embedded human lung carcinoma tissue.
Western blot of ZIP-kinase (K261) pAb in extracts from HUVEC cells.

DAPK3 / ZIP Kinase Antibody LS-C658823
Rabbit Polyclonal to Human DAPK3 / ZIP Kinase
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $305.00

DAPK3 / ZIP Kinase Antibody (aa279-298) LS-C83379
Rabbit Polyclonal (IgG) to Human DAPK3 / ZIP Kinase
Human
ICC WB
Unconjugated
100µg  $415.00
Immunocytochemical staining of ZIP kinase in Jurkat cells with ZIP kinase antibody at 10µg/ml.
Western blot analysis of ZIP kinase in HeLa (H) and Jurkat (J) cell lysates with ZIP kinase antibody at 1 g/ml.
Immunocytochemical staining of ZIP kinase in Jurkat cells with ZIP kinase antibody at 10µg/ml.
Western blot analysis of ZIP kinase in HeLa (H) and Jurkat (J) cell lysates with ZIP kinase antibody at 1 g/ml.
Showing 1-25 of 50 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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