DAP10

hematopoietic cell signal transducer

Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.

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Proteins (5)

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Over-Expression Lysate (4)

Recombinant (1)

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DAP10 (5)

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No (5)

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Myc-DDK (Flag) (5)

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Human (3)

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293T Cells (2)

HEK 293 Cells (3)

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DAP10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121991

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.49 kDa

Price:

100 µg/$494

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Human DAP10 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69530

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

7.3 kDa

Price:

20 µg/$1,107

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Human DAP10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84883

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.49 kDa

Price:

20 µg/$150

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Human DAP10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84884

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.49 kDa

Price:

20 µg/$150

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DAP10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101183

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.49 kDa

Price:

100 µg/$494

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