DACH / DACH1

dachshund family transcription factor 1

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

DACH / DACH1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human DACH / DACH1 Protein (Recombinant GST, N-terminus) (aa596-704) - LS-G58290

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DACH / DACH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88937

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73 kDa

Price:

20 µg/$215

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DACH / DACH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107777

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73 kDa

Price:

100 µg/$710

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