DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.

☰ Filters

Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

DAB2 (6)

Publications

No (6)

Tag

GST (2)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (2)

Select

Human DAB2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65403

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.3 kDa

Price:

20 µg/$1,107

Select

Human DAB2 Protein (Recombinant GST, N-terminus) (aa673-770) - LS-G58288

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human DAB2 Protein (Recombinant GST) (Full Length) - LS-G28147

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110.22 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human DAB2 Protein (Recombinant GST) (Full Length) - LS-G28148

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

108.8 kDa

Price:

10 µg/$479; 25 µg/$670

Select

DAB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99417

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.3 kDa

Price:

100 µg/$494

Select

Human DAB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75502

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.3 kDa

Price:

20 µg/$150

Viewing 1-6 of 6 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.