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DAB1

Dab, reelin signal transducer, homolog 1 (Drosophila)

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Gene Name: Dab, reelin signal transducer, homolog 1 (Drosophila)
Synonyms: DAB1, Disabled homolog 1
Target Sequences: NM_021080 NP_066566.3 O75553

Publications (1)

1
Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways. Hughes S, Rodgers J, Hickey D, Foster RG, Peirson SN, Hankins MW. Scientific reports. 2016 6:28086. (WB; Human) [Full Text Article] [PubMed:27301998] [PMC:PMC4908426] Related Antibodies: LS-B9240.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
DAB1 (5)
No (5)
GST (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (3)
Rat (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
DAB1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.8 kDa
20 µg/$215
DAB1 Protein - Recombinant  Disabled Homolog 1 By SDS-PAGE
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E. coli
His-T7
17.9 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
DAB1 Protein - 12.5% SDS-PAGE of human DAB1 stained with Coomassie Blue
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Wheat Germ Extract
GST
86 kDa
10 µg/$479; 25 µg/$670
DAB1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.8 kDa
100 µg/$710
DAB1 Protein - Purified recombinant protein DAB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
59.8 kDa
20 µg/$1,107
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).