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CYTH2 / Cytohesin 2

cytohesin 2

CYTH2 / Cytohesin 2 is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: cytohesin 2
Synonyms: CYTH2, ARF exchange factor, ARNO, Cytohesin 2, Cytohesin-2, PSCD2, PSCD2L, Sec7p-L, SEC7L, Sec7p-like, Protein ARNO, CTS18, CTS18.1
Target Sequences: NM_017457 NP_059431.1 Q99418

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
CYTH2 / Cytohesin 2 (7)
No (7)
GST (1)
GST, N-terminus (1)
His (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
CYTH2 / Cytohesin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$150
CYTH2 / Cytohesin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
46.4 kDa
100 µg/$494
CYTH2 / Cytohesin 2 Protein - Recombinant  Cytohesin 2 By SDS-PAGE
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E. coli
His-T7
49.2 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
CYTH2 / Cytohesin 2 Protein - 12.5% SDS-PAGE of human CYTH2 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.9 kDa
10 µg/$479; 25 µg/$670
CYTH2 / Cytohesin 2 Protein - Purified recombinant protein CYTH2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$1,107
CYTH2 / Cytohesin 2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CYTH2 / Cytohesin 2 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).