Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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CYSLTR1 / CYSLT1
cysteinyl leukotriene receptor 1
Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity ( Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma.
Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction. Sekioka T, Kadode M, Fujii M, Kawabata K, Abe T, Horiba M, Kohno S, Nabe T. Allergology international : official journal of the Japanese Society of Allergology. 2015 October;64:351-8. (Human)[Full Text Article]
Related Antibodies: LS-A1317.