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CYR61

cysteine-rich, angiogenic inducer, 61

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Name: cysteine-rich, angiogenic inducer, 61
Synonyms: CYR61, GIG1, IGFBP10, Protein CYR61, CCN family member 1, CCN1, IBP-10, IGF-binding protein 10, IGFBP-10, Protein GIG1
Target Sequences: NM_001554 NP_001545.2 O00622

Publications (2)

1
Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium. Gashaw I, Stiller S, Bing C, Kimmig R, Winterhager E. Endocrinology. 2008 149:2261-9. (ICC, IHC) [PubMed:18202125]
2
Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Haseley A, Boone S, Wojton J, Yu L, Yoo JY, Yu J, Kurozumi K, Glorioso JC, Caligiuri MA, Kaur B. Cancer research. 2012 72:1353-62. [PubMed:22282654] [PMC:PMC3366191]

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Antibodies (40)
Primary (40)
CYR61 (40)
Human (29)
Mouse (19)
Rat (9)
Bat (3)
Chimpanzee (3)
Gibbon (3)
Horse (3)
Monkey (3)
Rabbit (3)
Sheep (1)
IHC (10)
IHC-Fr (1)
IHC-P (4)
WB (33)
ELISA (11)
ICC (1)
IF (1)
Peptide-ELISA (1)
rabbit (35)
mouse (2)
rat (1)
sheep (2)
Product Group
IHCPlus (2)
IgG (12)
IgG1,k (1)
IgG2a,k (1)
IgG2b (1)
monoclonal mc (3)
polyclonal pc (37)
3C11 (1)
APC (2)
APC Conjugated (2)
Biotin Conjugated (4)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (20)
aa176-379 (8)
aa178-381 (8)
aa100-149 (4)
aa120-220 (1)
aa143-174 (1)
aa150-250 (1)
aa168-242 (1)
aa176-281 (1)
aa22-381 (1)
aa47-332 (1)
aa54-381 (1)
No (40)
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CYR61 Rat anti-Mouse Monoclonal (aa176-281) Antibody
Mouse
ELISA, IHC
Unconjugated
100 µg/$884
CYR61 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using CYR61 Polyclonal Antibody at dilution of 1:60.
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CYR61 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CYR61 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CYR61 Rabbit anti-Human Polyclonal (aa150-250) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$485
CYR61 Antibody - Human Colon, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CYR61 Rabbit anti-Human Polyclonal (aa47-332) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$575
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CYR61 Rabbit anti-Human Polyclonal Antibody
Sheep, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
20 µl/$508; 100 µl/$996
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CYR61 Mouse anti-Human Monoclonal (aa168-242) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$586
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CYR61 Sheep anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, WB
Unconjugated
100 µg/$930
CYR61 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using CYR61 Polyclonal Antibody at dilution of 1:50.
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CYR61 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CYR61 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using CYR61 Antibody at dilution of 1:100
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CYR61 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$294; 100 µg/$360
CYR61 Antibody - Western blot analysis of Jurkat cell lysate.
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CYR61 Rabbit anti-Human Polyclonal (aa120-220) Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CYR61 Rabbit anti-Mouse Polyclonal Antibody
Mouse
IHC-P, WB
Unconjugated
50 µg/$448
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CYR61 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
CYR61 Antibody - Anti-CYR61 Antibody (Center) at 1:2000 dilution + MDA-MB-231 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 42 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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CYR61 Rabbit anti-Human Polyclonal (aa143-174) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
CYR61 Antibody - Immunofluorescence analysis of L929 cells using CYR61 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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CYR61 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CYR61 Antibody - Detection limit for recombinant GST tagged CYR61 is 1 ng/ml as a capture antibody.
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CYR61 Mouse anti-Human Monoclonal (3C11) Antibody
Human
ELISA
Unconjugated
100 µg/$423
CYR61 Antibody - Western blot of recombinant CYR61.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Mouse Polyclonal (aa176-379) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
CYR61 Antibody - Western blot of recombinant CYR61.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Mouse Polyclonal (aa176-379) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
CYR61 Antibody - Western blot of recombinant CYR61.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Mouse Polyclonal (aa176-379) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
CYR61 Antibody - Western blot of recombinant CYR61.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Mouse Polyclonal (aa176-379) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
CYR61 Antibody - Western blot of recombinant CYR61.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Mouse Polyclonal (aa176-379) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
CYR61 Antibody - CCN1 antibody Western blot. All lanes: Anti CCN1 at 0.5 ug/ml. Lane 1: Rat Thymus Tissue Lysate at 50 ug. Lane 2: Rat Skeletal Muscle Tissue Lysate at 50 ug. Lane 3: A431 Whole Cell Lysate at 40 ug. Lane 4: SGC Whole Cell Lysate at 40 ug. Lane 5: 22RV1 Whole Cell Lysate at 40 ug. Predicted band size: 42 kDg. Observed band size: 42 kD.
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CYR61 Rabbit anti-Human Polyclonal (aa54-381) Antibody
Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
CYR61 Antibody - CYR61 antibody Western Blot of COLO205. Antibody dilution: 3 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Human Polyclonal (aa100-149) Antibody
Human
WB
Unconjugated
100 µl/$397
CYR61 Antibody - Western blot of recombinant CYR61.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Human Polyclonal (aa178-381) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
CYR61 Antibody - Western blot of recombinant CYR61.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYR61 Rabbit anti-Human Polyclonal (aa178-381) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
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CYR61 Sheep anti-Human Polyclonal (aa22-381) Antibody
Human
WB
Unconjugated
100 µg/$930
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).